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גלי מוח: קוגניציה, ביולוגיה ומה שביניהם - מפגש שני (15.1.20): Resonance, oscillation and the intrinsic frequency preferences of neurons | לימוד בחברותא

גלי מוח: קוגניציה, ביולוגיה ומה שביניהם - מפגש שני (15.1.20): Resonance, oscillation and the intrinsic frequency preferences of neurons

 

Meeting summary:

The second meeting took place in the Psychology department, Mount Scopus campus, at 15.01.2019.

Nora led the discussion about Hutcheon & Yarom (2000) “Resonance, oscillation and the intrinsic frequency preferences of neurons” from Trends in neurosciences. The authors first differentiate resonance (or impedance) - the property of certain neurons to respond more strongly to input at certain frequencies more than at other frequencies - and spontaneous oscillations which do not require any input current to the neurons. A simple biological mechanism for resonance is then provided. It is made of a low pass filter, which all cells have owing to the properties of their membranes and leak channels, and a high pass filter, which is made of active currents that oppose currents flowing through the neuronal membrane, such as the Ih current (HCN channels). Neurons can oscillate when additional “amplifying” currents are also present. These are currents that amplify rather than oppose currents flowing the membrane. The main topic that was discussed during the meeting was how these properties of single neurons and subthreshold oscillations relate to oscillations measured in the field potential, which supposedly arise from action potentials (and the postsynaptic dendritic potentials resulting from them). Specifically, resonance peaks in pyramidal cells were measured in the range of up to 30 Hz or so, but gamma oscillations are usually in the range of 30-70 Hz. This would mean that gamma oscillations are actually suboptimal from the perspective of the receiving cells resonance. It is possible that the specific resonance being measured is not the one relevant to the population oscillation. Furthermore, how do the properties of single cells properties support other notions related to population oscillations such as spike phase locking?

The group decided to take the relationship between signals in individual neurons and field potentials as the topic for the next meeting, as this would seem to be the next step along the way to understanding how high-frequency oscillations can emerge from the activity of individual neurons. This next meeting will be led by one of the participants (Vitaly) who has considerable expertise on the topic.

 

Participants:

Yaron Cohen

Noa Rahamin

Vitaly Lerner

Inbar Kotzer

Carmel Ash

Ruoyi Cao

Noam Schwartz

Lorenzo Guarnieri

Lena Gorina

Nora Vrieler

Nir Ofir